論文
独創的な研究に基づいた新しい価値を社会実装し、すべての人々の生活に貢献することを目指します。これらの学術的な発見は多くの革新的な化粧品に繋がっています。
Factors Affecting Reduction in Preservative Efficacy in Nonwoven Fabrics
Usukura J., Endo Y., Mune M.
Biocontrol Sci, 25(3), 149-157 (2020)
Molecular Mechanisms of Sensory Perception on Skin Surface and the Applications for Cosmetics
Fujita F.
J. Soc. Cosmet. Chem. Jpn, 54(3), 225-228 (2020)
Hypotonicity-induced cell swelling activates TRPA1
Fujita F., Uchida K., Takayama Y., Suzuki Y., Takaishi M., Tominaga M.
J Physiol Sci, 68(3), 431-440 (2018)
An Offensive Defense: Minimizing Preservatives, Maximizing Protection and Resources
Araki H., Hamada S., Toshima Y., Kawazoe Y., Otani M., Suzuki R., Usukura J., Ookawa M.
Cosmet Toilet Mag, Mar., 64-78(2018)
Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining
Kurata R., Futaki S., Nakano I., Fujita F., Tanemura A., Murota H., Katayama I., Okada F., Sekiguchi K.
PLoS One, 12, e0178709 (2017)
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure
Toriyama Ma., Toriyama Mi., Wallingford J.B., Finnell R.H.
FASEB J, 31, 3622-3635 (2017)
Reciprocal effects of capsaicin and menthol on thermo-sensation through regulated activities of TRPV1 and TRPM8
Takaishi M., Uchida K., Suzuki Y., Matsui H., Shimada T., Fujita F., Tominaga M.
J Physiol Sci, 66, 143-155 (2016)
The influence of humidity on the transfer of scalp sebum to hair
Tsumura A., Saito K., Fujii N., Fujita F., Hisahara J., Ohno K.
J. Soc. Cosmet. Chem. Jpn, 50, 33-40 (2016)
Cold perception on skin surface through thermo- receptors (A review)
Fujita F., Takaishi M.
Household and Personal Care Today, 10, 24-26 (2015)
Evaluation of the Comfortable Cooling Sensation for the Development of Body Care Products
Shimada T., Matsui H., Sawada M., Takaishi M., Fujita F.
Oleoscience, 15, 415-422 (2015)
Gap junction-mediated contraction of myoepithelial cells induces the peristaltic transport of sweat in human eccrine glands
Nakashima K., Kato H., Kurata R., Luo Q., Hayakawa T., Okada F., Fujita F., Nakagawa Y., Tanemura A., Murota H., Katayama I., Sekiguchi K.
Commun Biol., Nov 18;6(1):1175 (2023)
Dendritic cell proliferation by primary cilium in atopic dermatitis
Toriyama M., Rizaldy D., Nakamura M., Atsumi Y., Toriyama M., Fujita F., Okada F., Morita A., Itoh H., Ishii K.J.,
Front. Mol. Biosci., 10:1149828 (2023)
Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent
Saito K.O., Fujita F., Toriyama M., Utami R.A., Guo Z., Murakami M., Kato H., Suzuki Y., Okada F., Tominaga M., Ishii K.J.
Biochem Biophys Res Commun, 654:1-9 (2023)
Basal cell carcinoma of the umbilicus associated with sweat gland structures: Two case reports
Kurosaki Y., Itoi-Ochi S., Ota A., Miyazaki A., Kato H., Nojima S., Morii E., Yokoi K., Fujimoto M., Tanemura A.
Medicine, 2023;102:8(e33128) (2023)
Anti-Inflammatory Role of TRPV4 in Human Macrophages
Atsumi Y., Toriyama M., Kato H., Nakamura M., Morita A., Takaishi M., Saito K.O., Tanaka M., Okada F., Tominaga M., Ishii K.J., Fujita F.
ImmunoHorizons, 1;7(1):81-96 (2023)
Establishment and characterization of immortalized sweat gland myoepithelial cells
Hayakawa T., Fujita F., Okada F., Sekiguchi K.
Sci Rep Jan ,7;12(1):7 (2022)
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis
Rizaldy D., Toriyama M., Kato H., Fukui R., Fujita F., Nakamura M., Okada F., Morita A., Ishii K.J.
Exp Dermatol, 30, 792-803 (2021)
Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential
Toriyama M., Ishii K.J.
Front Cell Dev Biol, 621318 (2021)
Metabolomic Alteration of Oral Keratinocytes and Fibroblasts in Hypoxia
Kato H., Sugimoto M., Enomoto A., Kaneko M., Hara Y., Saito N., Shiomi A., Ohnuki H., Izumi K.
J. Clin. Med., 10(6), 1156-1167 (2021)
Comparison of Different Temperature Conditions for Microbial Enumeration of Aspergillus brasiliensis in the Preservative Efficacy Test
Usukura J.
Biocontrol Sci,in press (2021)
2014
Effect of the application of facial cleansing wipes on male skin conditions.
Shimada T., Saito K., Takaishi M., Usukura J., Yamaguchi A., Fujita F., Shimizu M.
J. Soc. Cosmet. Chem. Jpn, 48(4), 306-311 (2014)
Isolation and characterization of sweat gland myoepithelial cells from human skin.
Kurata R., Futaki S., Nakano I., Tanemura A., Murota H., Katayama I., Sekiguchi K.
Cell Struct Funct., 39, 101-112 (2014)
Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.
Takaishi M., Uchida K., Fujita F., Tominaga M.
J Physiol Sci, 64, 47-57 (2014)
2013
Ambient temperature affects the temperature threshold for TRPM8 activation through interaction phosphatidylinositol 4,5-bisphosphate.
Fujita F., Uchida K., Takaishi M., Sokabe T., Tominaga M.
J Neurosci, 33, 6154-6159 (2013)
2012
Transient receptor potential channels in sensory irritation.
Fujita F.
Household and Personal Care Today, 7, 21-24 (2012)
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Takaishi M., Fujita F., Uchida K., Yamamoto S., Sawada Shimizu M., Hatai Uotsu C., Shimizu M, Tominaga M.
Mol Pain, 8, 86 (2012)
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.
Komatsu T., Uchida K., Fujita F., Zhou Y., Tominaga M.
Pflugers Arch., 463, 549-59 (2012)
Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells.
Nishinaga M., Kurata R., Onishi K., Kuriyama K., Wakasugi M., Matsunaga T.
Photochem Photobiol., 88, 356-362 (2012)
2010
Inhibition of the CXCR3-mediated pathway suppresses ultraviolet ray B-induced pigmentation and erythema in skin.
Kurata R., Fujita F., Onishi K., Kuriyama K., Kawamata S.
Br. J. Dermatol., 163, 593-602 (2010)
Significance of hair-dye base-induced sensory irritation.
Fujita F., Azuma T., Tajiri M., Okamoto H., Sano M., Tominaga M.
Int J Cosmet Sci., 32, 217-224 (2010)
2008
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice.
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest., 118, 4049-4057 (2008)
The Effect of Triclosan and 3-methyl-4-isopropylphenol in Combination on Axillary Microflora.
Endo Y., Okamoto H., Okada F.
Boukin Boubai., 36(10), 653-660 (2008)
2007
Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Fujita F., Moriyama T., Higashi T., Shima A., Tominaga M.
Br. J. Pharmacol., 151,153-60 (2007)
1999
Calorimetric Study of the Antimicrobial Action of Various Polyols Used for Cosmetics and Toiletries.
Aono A., Takahashi K., Mori N., Shimizu H., Kobayashi A., Fujiwara N., Okada F.
Netsu Sokutei., 26(1), 2-8 (1999)
Calorimetric Analysis of Antimicrobial Effect of p-hydroxybenzoic Acid Alkyl Esters.
Okada F., Kobayashi A., Fujiwara N., Arimoto N., Takahashi K.
Biocontrol Science, 4, 67-73 (1999)
Bacteriostatic and Bactericidal Actions of Antimicrobial Drugs Studies by Microbial Calorimetry.
Okada F., Kobayashi A., Fujiwara N., Takahashi K.
Biocontrol Science, 4, 35-39 (1999)
1998
Microbial Calorimetry of Supported Cultures and Its Application to the Study of Antimicrobial Action.
Okada F., Kobayashi A., Fujiwara N., Takahashi K.
Biocontrol Science, 3, 79-85 (1998)
Quantitative Analysis of Antimicrobial Actions of Drugs Studied by Microbial Calorimetry.
Okada F.
Netsu Sokutei., 25(4), 132-137 (1998)
Simplified, Time-saving Microbial Tests for Cosmetics and Toiletories.
Okada F.
J. Soc. Cosmet. Chem. Jpn., 32(2), 131-139 (1998)
1993
Preservative Evaluation of Cosmetics and Toiletories by Microbial Calorimetry.
Okada F., Fujiwara N., Matsuyama K., Takahashi, K.
J. Soc. Cosmet. Chem. Jpn., 27(3), 242-248 (1993)
Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response
Guo Z., Murakami M., Saito K.O., Kato H., Toriyama M., Tominaga M., Ishii K.J., Fujita F.
Exp Dermatol., 2024 Mar;33(3):e15021 (2023)
Next-Generation Antiperspirant Technique: Controlling the Contraction of Human Eccrine Gland
Hara T., Kyuka A., Nakashima K., Kato H., Fujita F., Luo Q., Hayakawa T., Tanemura A., Nakagawa Y., Murota H., Katayama I., Sekiguchi K.
IFSCC Magazine., 26(4) 287-294 (2024)
Aluminum potassium sulfate inhibits TRPV1 and TRPA1 activation
Aoki H., Takaishi M., Usukura J., Hara T., Ishii K.J., Tominaga M., Fujita F.
Pain Research, 2025. Vol. 40. No. 1. pp. 31-36.
Long-Term Hypoxia Upregulates Wnt and TGFβ1 Signaling in Eccrine Sweat Gland Cells in vitro
Lyu Y., Kato H., Luo Q., Otani N., Kubo T., Sekiguchi K., Fujita F.
Int J Mol Sci, 2025. Vol. 26. No. 14. 6664.
UV-A radiation impairs sebaceous-gland-related skin barrier function by inducing inflammation and altering intracellular sebum-like lipid composition
Dong W., Kono M., Takaishi M., Kyuka A., Kato H., Fujita F.
J Cosmet Dermatol, 2025. Vol. 24. No. 10. e70392.
Relationship between sensory irritation on skin surface and TRP channel activatio
Fujita F., Takaishi M., Iwashita S., Yoshikawa K., Sawada M., Shimizu H., Nagamatsu M., Shiomi Y., Hara T., Ishida K., Uchida K., Suzuki Y., Tominaga M.
J Physiol Sci, 76, 100096 (2026)
Kukui nut oil (Aleurites moluccanus seed oil) promotes hair growth by activating the Nrf2/ARE-AKR1C family-PGF2α signaling axis
Kato H., Badjuri NR., Febrian J., Erawati T., Rijal MAS., Rizaldy D.,
Sai S., Fukui R., Atsumi Y., Hayakawa T, Saito-Otsuka K., Hara T., Fujita F.
Sci Rep., 16, 24694 (2026)
MA-T activates human TRPV4 in the non-pigmented ciliary epithelial cells
Luo Q., Toriyama M., Hashimoto M., Tominaga M., Inoue T., Fujita F.
Biol and Pharm Bull, 2026. Vol. 49. No. 1. pp. 149-153.